Of those newly eligible under 2021 criteria, 2,063,840 were aged 50 to 54 years and 4,020,879 had 20 to 29-pack-year smoking history
Updated guidelines recommend annual screening for those aged 50 to 80 years who currently smoke, or formerly smoked
PLCOm2012 models have higher sensitivity than USPSTF criteria, with no difference by Indigenous classification
Model relies only on age, smoking duration, and pack-years
Meta-analysis only shows a 110-day survival benefit for colorectal cancer screening with sigmoidoscopy
Single-site cancer screening could save an additional 3.2 to 5.1 million life-years with perfect adherence
AUROC estimate of four-marker protein panel plus PLCO<sub>m2012</sub> was 0.88 for risk prediction of lung cancer death
Yet, variation in uptake seen by geography, race, smoking history, and age
Black veterans had 34 percent lower odds of screening completion versus White veterans
Risk model-based lung cancer screening strategy more cost-effective than 2021 USPSTF recommendations